Biological Activity for Substance P
Substance P is a sensory neuropeptide and inflammatory mediator. Exerts excitatory effects on central and peripheral neurons, constricts bronchioles and is involved in pain transmission.
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Technical Data for Substance P
|Sequence|| RPKPQQFFGLM |
(Modifications: Met-11 = C-terminal amide)
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
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References for Substance P
References are publications that support the biological activity of the product.
Andoh et al (1998) Substance P induction of itch-associated response mediated by cutaneous NK1 tachykinin receptors in mice. J.Pharmacol.Exp.Ther. 286 1140 PMID:9732370 Pernow et al (1983) Substance P. Pharmacol.Rev. 35 85 PMID:6196797 Walsh et al (1995) Substance P-induced inflammatory responses in guinea-pig skin: the effect of specific NK1 receptor antagonists and the role of endogenous mediators. Br.J.Pharmacol. 114 1343 PMID:7541689 Merck Index 12 9032 If you know of a relevant reference for Substance P, please let us know.
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Keywords: Substance P, Substance P supplier, Sensory, neuropeptide, inflammatory, mediators, Tachykinin, Non-Selective, Neurokinin, Receptors, agonists, SubstanceP, neuropeptides, Other, 1156, realchampionshipwrestling.com Bioscience
15 Citations for Substance P
Citations are publications that use realchampionshipwrestling.com products. Selected citations for Substance P include:
Howe et al (2004) Role of neurokinin 3 receptors in supraoptic vasopressin and oxyt. neurons. J Biomol Screen 24 10103 PMID:15537880
Alsaqati et al (2013) Investigation of the functional expression of purine and pyrimidine receptors in porcine isolated pancreatic arteries. Purinergic Signal 10 241 PMID:24310605
Hur and Park (2013) Long-term potentiation of excitatory synaptic strength in spinothalamic tract neurons of the rat spinal cord. Korean J Physiol Pharmacol 17 553 PMID:24381506
Hanson et al (2009) A homogeneous fluorescent live-cell assay for measuring 7-transmembrane receptor activity and agonist functional selectivity through β-arrestin recruitment. Antioxid Redox Signal 14 798 PMID:19531663
Li et al (2009) Activation of glycogen synthase kinase-3 β is required for hyperDA and D2 receptor-mediated inhibition of synaptic NMDA receptor function in the rat prefrontal cortex. J Neurosci 29 15551 PMID:20007479
Gutierrez and Boada (2019) Neuropeptide-induced modulation of carcinogenesis in a metastatic breast cancer cell line (MDA-MB-231LUC+). Cancer Cell Int 18 216 PMID:30598641
Nogueras-Ortiz (2017) Retromer stops beta-arrestin 1 mediated signaling from internalized cannabinoid 2 receptors. Mol Biol Cell 28 3554 PMID:28954865
Wan et al (2017) Endomorphin-2 Inhibition of Substance P Signaling within Lamina I of the Spinal Cord Is Impaired in Diabetic Neuropathic Pain Rats. Front Mol Neurosci 9 167 PMID:28119567
Fisher et al (2015) Increased CCN2, substance P and tissue fibrosis are associated with sensorimotor declines in a rat model of repetitive overuse injury. J Cell Commun Signal 9 37 PMID:25617052
Robery et al (2011) Investigating the effect of emetic compounds on chemotaxis in Dictyostelium identifies a non-sentient model for bitter and hot tastant research. PLoS One 6 e24439 PMID:21931717
Shanley et al (2011) Evidence for regulatory diversity and auto-regulation at the TAC1 locus in sensory neurones. J Neurosci 8 10 PMID:21294877
Kowtharapu et al (2018) Role of Corneal Stromal Cells on Epithelial Cell Function during Wound Healing. Int J Mol Sci 19 PMID:29401709
Frara et al (2018) Substance P increases CCN2 dependent on TGF-beta yet Collagen Type I via TGF-beta1 dependent and independent pathways in tenocytes. Connect Tissue Res 59 30 PMID:28399671
Chen et al (2014) μ-Opioid receptor inhibition of substance P release from primary afferents disappears in neuropathic pain but not inflammatory pain. Neuroscience 267 67 PMID:24583035
Wease and Davies (2005) Substance P selectively decreases paired pulse depression in the rat hippocampal slice. BMC Neurosci 6 66 PMID:16305744
Do you know of a great paper that uses Substance P from realchampionshipwrestling.com? Please let us know.